intensification of anemia by secondary hyperparathyroidism in hemodialysis patients

نویسندگان

h. nasri hajar hospital, section of dialysis, shahrekord, iran.

چکیده

the excessive amounts of parathyroid hormone in secondary hyperparathyroidism (shpth) is suggested to interfere with normal erythropoiesis.  in shpth, during chronic renal failure, due to the impairment of erythropoietin synthesis, this effect is more pronounced.  in the present study the role of secondary hyperparathyroidism in the severity of anemia was evaluated in hemodialysis patients (n=36; 16 females and 20 males) with the end-stage renal failure.  cbc, hgb, hct, calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (ipth), serum iron, total iron binding capacity, transferin saturation, ferritin as well as dialysis adequacy were measured.  partial correlation test was performed for analysis of the data making adjustments for age, duration of hemodialysis and ferritin levels.  the mean±sd for ipth, hgb and hct were 439.4 ± 433 pg/ml, 9 ± 1.9 and 28.8 ± 6.3 respectively.  the mean duration of hemodialysis for the patients was 25.1 ± 24 months.  a reverse correlation was found between ipth and hct and hgb as well as between alkaline phosphatase and hgb and hct (0<0.05).  it was shown that severity of hyperparathyroidism correlated with severe of anemia.  it is concluded that secondary hyperparathyroidism per se can intensify anemia in hemodialysis patients.  a more efficient control of hyperphosphatemia and parathormone hypersecretion is thus needed to achieve a better management of anemia in hemodialysis patients.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Intensification of Anemia by Secondary Hyperparathyroidism in Hemodialysis Patients

The excessive amounts of parathyroid hormone in secondary hyperparathyroidism (SHPTH) is suggested to interfere with normal erythropoiesis.  In SHPTH, during chronic renal failure, due to the impairment of erythropoietin synthesis, this effect is more pronounced.  In the present study the role of secondary hyperparathyroidism in the severity of anemia was evaluated in hemodialysis patients (n=3...

متن کامل

Intensification of Anemia by Secondary Hyperparathyroidism in Hemodialysis Patients

The excessive amounts of parathyroid hormone in secondary hyperparathyroidism (SHPTH) is suggested to interfere with normal erythropoiesis. In SHPTH, during chronic renal failure, due to the impairment of erythropoietin synthesis, this effect is more pronounced. In the present study the role of secondary hyperparathyroidism in the severity of anemia was evaluated in hemodialysis patients (n=36;...

متن کامل

Impacts of parathyroidectomy on renal anemia and nutritional status of hemodialysis patients with secondary hyperparathyroidism.

The aim of this study was to investigate the impacts of parathyroidectomy (PTX) towards the renal anemia and nutritional status of hemodialysis patients with secondary hyperparathyroidism (SHPT). 32 patients, enrolled into the blood purification center of our hospital for the hemodialysis treatment, were collected and divided into the PTX group and the non-PTX group, with 16 patients in each gr...

متن کامل

Secondary hyperparathyroidism in chronic hemodialysis patients in Khuzestan province, Iran

Introduction End-stage renal disease (ESRD) is a life-threatening disease with significant complication and the incidence and prevalence of this disease have signi ficantly increased in recent years and imposes a major social and economic burden for healthcare systems (1,2). As seen worldwide, it is well-established that diabetic nephropathy particularly from type 2 diabetes, and hypertensive n...

متن کامل

Parathyroidectomy reduces intradialytic hypotension in hemodialysis patients with secondary hyperparathyroidism.

BACKGROUND Secondary hyperparathyroidism is associated with vascular calcification and arterial stiffness in patients with end-stage renal disease. The aim of this study was to analyze the frequency of intradialytic hypotension (IDH) and cardiovascular function before and after parathyroidectomy (PTX) in maintenance hemodialysis patients. METHODS We compared predialytic and intradialytic bloo...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of medical sciences

جلد ۲۸، شماره ۴، صفحات ۱۹۵-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023